| CBDA has made the tabloids a few times now for its anti-viral, anti-Covid 19 properties, but did you know that it is also good for so many other things? Inflammation CBDA has anti-inflammatory characteristics, and may be able to relieve inflammation due to its characteristics as a selective Cox-2 inhibitor. Cyclooxygenase (Cox) enzymes 1 and 2 have different responsibilities. Cox-1 is responsible for maintaining the stomach and intestinal lining. Cox-2 causes inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin work by inhibiting the effects of both these enzymes. However, these drugs for the long-term, can cause damage to the gastrointestinal tract. For this reason, researchers have been focused on creating selective Cox-2 inhibitors that avoid inhibiting Cox-1 enzymes without the risk for major damage to the stomach and intestinal lining. CBDA works in the same way as NSAIDS but without eliminating the Cox-2 inhibitor. Therefore, you don’t get any damaging effects to the gut. Tumor A study focusing on the down regulation Cox-2 enzymes found that CBDA could help suppress the spread of a specific type of breast cancer cells. In this type of cancer, the concentration of Cox-2 is higher than average. During the study, CBDA was used for a period of 48 hours. While it helped inhibit Cox-2, it also reduced the effectiveness of the Id-1 protein, associated with inducing cancer cell growth and survival. In addition, CBDA seems to increase Sharp-1 expression, associated with suppressing breast cancer metastasis. While more studies are needed into its effects on cancer, CBDA is showing great promise in its suppression of these harmful cells in the body. Nausea Researchers have found that CBDA is a potent medicine against nausea and vomiting caused by toxin- and motion-induced vomiting and nausea. In particular, the research found that CBDA was incredibly effective at reducing anticipatory nausea. This occurs when a person feels nauseous right before chemotherapy treatment. Since this form of nausea has no known treatments, CBDA is an incredibly promising route. In a separate study, the research team tested the effects of a CBDA and ondansetron, an anti-nausea drug. The team found that even a very low dose of CBDA improves the drug’s antiemetic effect. A CBDA dose 1000 times less than CBD has the same effect. Seizures We all know that CBD has had incredible effects on seizures and epilepsy. This was one of the first things most people knew about CBD. With CBDA being much stronger than CBD, the effects are much greater. GW Pharma, the pharmaceutical company responsible for Epidiolex (an FDA approved cannabis-derived prescription drug for drug-resistant epilepsy) has performed studies comparing the effects of CBDA vs CBD. In some studies, the team found that CBDA can have better bioavailability and a faster-acting effect than its parent compound CBD. Essentially, their studies concluded that lower doses of CBDA were required to be effective, thereby lowering the risk of negative CBDA side effects. In some cases, CBDA proved more effective in reducing seizures compared to CBD. |
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